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Objective: To evaluate the effectiveness of corneal confocal microscopy, its parameters, and threshold as an early diagnostic method for diabetic neuropathy
Method: A systematic review was conducted through PubMed, CENTRAL, and Scopus, searching for studies implementing corneal confocal microscopy (CCM) in patients with diabetes for detecting neuropathy in the early stage. Quality assessment of studies selected were performed using selected risk-of-bias assessment tool.
Results: The search yielded 9 studies with a total of 2027 subjects. From the 9 studies reviewed, CCM proved to be a reliable method of diagnosis for diabetic neuropathy with consistent sensitivity and specificity. Fiber length, density, and bead size are the most reliable parameters for diagnosis.
Conclusion: Significant correlation between CCM parameters and diabetic neuropathy were found. Therefore corneal confocal microscopy showed promising potentials as an early diagnostic tool for diabetic neuropathy.
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