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The study determined the histopathologic and hematologic effects of Arthrospira platensis and Moringa oleifera Lam., and their synergism on tumor-induced Sprague- Dawley rats. Induction of tumors was done through intraperitoneal administration of 1,2- dimethylhydrazine and 7,12-dimethylbenz[a]anthracene for four weeks. Readily available capsules and tablets of Spirulina and malunggay mixed with water were used to achieve the desired 50% and 75% concentration. Intraperitoneal administration of the extracts and intravenous administration of 5-fluorouracil as the positive control treatment were done for two weeks post tumor induction. After treatment, representatives of each treatment groups were drawn blood and dissected for hematologic and histopathologic examination, respectively. Results show anti-tumor activity of all extracts in the liver in contrast to their ineffectiveness in the lungs. Furthermore, all but the 75% Spirulina extract were effective against gastric tumor development while both concentrations of Spirulina and its 75% concentration successfully countered development of tumors of the small intestine and large intestine, respectively. All of the extracts caused a general negative effect on the complete blood count. In conclusion, A. platensis proved to be the more effective against tumor development.
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