Statins and the COVID-19 Vaccines: a viewpoint

Main Article Content

Muhammad Sameer Arshad


The COVID-19 pandemic has caused many scientists to promptly make vaccines against the disease. A large number of people who will receive the vaccines will likely be older adults, many of whom being long-term statin users. Statins, known to be immunomodulators, can interact with vaccines and alter their effects. Whether this effect is significant or not is up for debate, like in the case of the influenza vaccine. Thus, the interaction between statins and the COVID-19 vaccines should be investigated and understood, and guidelines should be written to ensure that the vaccines perform optimally.

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How to Cite
Arshad, M. S. and Siddiqui, A. A. (2021) “Statins and the COVID-19 Vaccines: a viewpoint”, Journal of Asian Medical Students’ Association. Kuala Lumpur, Malaysia, 9(1). doi: 10.52629/jamsa.v9i1.253.
Perspective Article


. Gu Q, Paulose-Ram R, Burt VL, Kit BK. Prescription cholesterol-lowering medication use in adults aged 40 and over: United States, 2003-2012. NCHS Data Brief. 2014;(177):1-8.

. Terblanche M, Almog Y, Rosenson RS, Smith TS, Hackam DG. Statins and sepsis: multiple modifications at multiple levels. Lancet Infect Dis. 2007;7(5):358-368. doi:10.1016/S1473-3099(07)70111-1

. Black S, Nicolay U, Del Giudice G, Rappuoli R. Influence of Statins on Influenza Vaccine Response in Elderly Individuals. J Infect Dis. 2016;213(8):1224-1228. doi:10.1093/infdis/jiv456

. Omer SB, Phadke VK, Bednarczyk RA, Chamberlain AT, Brosseau JL, Orenstein WA. Impact of Statins on Influenza Vaccine Effectiveness Against Medically Attended Acute Respiratory Illness. J Infect Dis. 2016;213(8):1216-1223. doi:10.1093/infdis/jiv457

. Havers FP, Chung JR, Belongia EA, et al. Influenza vaccine effectiveness and statin use among adults in the United States, 2011-2017. Clin Infect Dis. 2019;68(10):1616-1622. doi:10.1093/cid/ciy780

. McLean HQ, Chow BDW, Vanwormer JJ, King JP, Belongia EA. Effect of Statin Use on Influenza Vaccine Effectiveness. J Infect Dis. 2016;214(8):1150-1158. doi:10.1093/infdis/jiw335

. Kadambari S, Klenerman P, Pollard AJ. Why the elderly appear to be more severely affected by COVID-19: The potential role of immunosenescence and CMV. Rev Med Virol. 2020;30(5). doi:10.1002/rmv.2144