A Comprehensive Look on Conjugated Targeted Therapies as A Novel Candidate for Personalized Thyroid Carcinoma Treatment

Abstract

Thyroid cancer is a substantial threat worldwide due to its prevalence and complication it follows. Current therapy is widely available, although failed to address the burdens associated with the disease, thus requiring a newer approach. Recently, the novel discovery of conjugated targeted therapy and its potential implementation enables a more specific, cancer-targeting mechanism, with potentially higher efficacy and minimum adverse effect than conventional treatments. This review was made to assess its potential, via comprehensive screening on several databases, such as Cochrane, PubMed, Scopus, ScienceDirect, and Wiley with set criterions. The search yielded 6 viable studies analyzing different forms of targeted therapies Based on the included studies, conjugated targeted therapy displayed high selectivity and cytotoxicity toward cancer cells, while remained tolerable toward normal cells and the host. Not only as a therapeutic agent, this therapy also possessed imaging enhancement and metastasis detection, indicating high diagnostic value. Although, applicability and cost- efficiency of the treatment should be considered, due to extra costs in biosynthesizing therapeutic agents and phenotyping of targeted cells. Nonetheless, the high selectivity and potentially better safety profile of conjugated targeted therapy should be assessed further, and weighed with its limitations. All in all, conjugated targeted therapy has been proven to be selective towards cancer cell and a potent candidate as personalized treatment. Biosafety analysis of its implementation is recommended, followed by further clinical trials on human samples.