Mobile-Based Telemedicine as a Milestone for Lifestyle Monitoring Non-Alcoholic Fatty Liver Disease Patients: A Systematic Review and Meta-Analysis

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Sena Pongtuluran
Jaun Alessandro Jeremis Maruli Nura Lele
Fanessa Pingkan Widytri Nugroho



NAFLD is the most common liver disease worldwide which can progress to fibrosis, cirrhosis, liver failure, hepatocellular carcinoma, and death. Currently, there is no therapeutic treatment and non-adherence to lifestyle modifications still possess problems. Diet and exercise are the main treatment for patients with NAFLD. Mobile-based telemedicine provides a powerful approach to dealing with behavioral changes.


The study aims to assess the efficacy of mobile-based telemedicine in improving liver function and body weight among NAFLD patients.


The literature search was performed using PubMed, Plos One, Proquest, EBSCO Essentials, Wiley, and Cochrane using the keyword: Non-alcoholic fatty liver disease, smartphone, and telemedicine. The data was screened based on inclusion and exclusion criteria. Risk of bias assessment was done using ROB 2.0 tool. Meta-analysis was done using Review Manager 4.1 to measure the mean difference of AST, ALT, and weight improvement.


Five randomized controlled trials with a 513 total number of participants were included. Overall study considered as low risk of bias. The meta-analysis showed AST, ALT and weight improvement with MD -9.68 (random effect; 95 % CI -16.48 to -2.88; P = 0.005), MD -19.72 (random effect; 95 % CI -32.26 to -7.18; P = 0.002), and MD -2.34 (fixed effect; 95% CI -3.52 to -1.15; P = 0.0001) respectively.


Mobile-based telemedicine has been proved to significantly improve liver function by reducing AST and ALT levels and body weight in NAFLD patients.

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How to Cite
Pongtuluran, S., Jaun Alessandro Jeremis Maruli Nura Lele and Fanessa Pingkan Widytri Nugroho (2022) “Mobile-Based Telemedicine as a Milestone for Lifestyle Monitoring Non-Alcoholic Fatty Liver Disease Patients: A Systematic Review and Meta-Analysis”, Journal of Asian Medical Students’ Association. Kuala Lumpur, Malaysia. Available at: (Accessed: 3December2022).
Scientific Posters (EAMSC 2023 Nepal)



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