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NAFLD is the most common liver disease worldwide which can progress to fibrosis, cirrhosis, liver failure, hepatocellular carcinoma, and death. Currently, there is no therapeutic treatment and non-adherence to lifestyle modifications still possess problems. Diet and exercise are the main treatment for patients with NAFLD. Mobile-based telemedicine provides a powerful approach to dealing with behavioral changes.
The study aims to assess the efficacy of mobile-based telemedicine in improving liver function and body weight among NAFLD patients.
The literature search was performed using PubMed, Plos One, Proquest, EBSCO Essentials, Wiley, and Cochrane using the keyword: Non-alcoholic fatty liver disease, smartphone, and telemedicine. The data was screened based on inclusion and exclusion criteria. Risk of bias assessment was done using ROB 2.0 tool. Meta-analysis was done using Review Manager 4.1 to measure the mean difference of AST, ALT, and weight improvement.
Five randomized controlled trials with a 513 total number of participants were included. Overall study considered as low risk of bias. The meta-analysis showed AST, ALT and weight improvement with MD -9.68 (random effect; 95 % CI -16.48 to -2.88; P = 0.005), MD -19.72 (random effect; 95 % CI -32.26 to -7.18; P = 0.002), and MD -2.34 (fixed effect; 95% CI -3.52 to -1.15; P = 0.0001) respectively.
Mobile-based telemedicine has been proved to significantly improve liver function by reducing AST and ALT levels and body weight in NAFLD patients.
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