Ulinastatin as a Potential Alternative Therapy for Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis

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Vito Filbert Jayalie
Arvin Pramudita
Windy Keumala Budianti


Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) is an emergency skin disease with high mortality rates despite the incidence rate is not great. Patients with SJS/TEN will experience reduced quality of life due to the pain experienced when eating, drinking or urinating. There is not a specific treatment for patient with SJS/TEN so far. Corticosteroids and intravenous immunoglobulin (IVIG) are the most commonly used therapies yet there are still controversies due to their positive and negative effects. Ulinastatin, a trypsin inhibitor and an anti-inflammatory compound that is made from human urine is a therapeutic option for SJS/TEN. Ulinastatin may provide anti-inflammatory effect by inhibiting TNF-α production, thereby reducing the risk of septic complications and lowering mortality. Until now, the known side effects are nausea, vomiting and allergic to gelatin. Although it has a promising potential, the effectiveness of ulinastatin is still poorly studied. Further research is needed regarding the usage of ulinastatin on patients with SJS/TEN.

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How to Cite
Jayalie, V. F., Pramudita, A. and Budianti, W. K. (2015) “Ulinastatin as a Potential Alternative Therapy for Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis”, Journal of Asian Medical Students’ Association. Kuala Lumpur, Malaysia, 4(1), pp. 25-39. Available at: https://jamsa.amsa-international.org/index.php/main/article/view/75 (Accessed: 28February2024).
Review and Meta-analysis